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diagnoSwiss S.A.
ZI Les Ilettes, Secteur 4        -        CH-1870 MONTHEY        -        Switzerland
Phone: +41 (0)24 473 75 40        -        Fax: +41 (0)24 473 75 41         -        E-mail: info@diagnoswiss.com        -        Web: www.diagnoswiss.com
  

Electrochemical detection

Signal detection occurs directly in the chip, by virtue of integrated micro-electrodes. The outcome of enzymatic substrate transformation is an electro-active product, which is measured by redox-cycling on the electrodes. The system makes use of conventional enzymes, such as horse radish peroxidase (HRP) or alkaline phosphatase (ALP).

Electrochemical detection offers several advantages over absorbance measurements:

The detected current is proportional to the analyte concentration (as opposed to depending on a total number of molecules, as is the case with luminescence measurement). Therefore, the response obtained in a miniaturized system is identical to that obtained in large volumes, and detection limits are readily brought to the pico-molar level in the micro-devices.

Moreover, electrochemical detection is not influenced by matrix opacity, which is particularly advantageous for direct measurements in serum, urine, CSF, and other matrixes.

Benefits

  • Reduced time-to-result: A full assay can be performed in 10-15 minutes due to the small reaction volume, and the particular design of the chips.

  • Convenience: Pocket-sized cartridges, handled with a minimum of care, are adapted to low sample and reagent consumption.

  • Cost-efficiency: Minimal reaction chamber volume implies >10-fold reduction in ELISA kit reagent consumption which results in the most competitive data-point pricing.

DiagnoSwiss chips: Biosensors for ultra-fast ELISA

Biosensor-Chip is the core element of diagnoSwiss technology. This consumable chip, which emanated from the combination of microfluidics and electrochemistry technologies, is a revolutionary device which is easily amenable to a wide range of analytical applications.

DiagnoSwiss chips are factually polymer cartridges with an array of micro-cells designed for running magnetic bead-based ELISA protocols with standard immunology reagents.

The micro-cells, with incorporated electrodes for electrochemical readout of enzymatic reactions, are suited for manual or automated use. With incubation times adapted to assay kinetics, beads and reagents are greatly pre--concentrated to yield results in the pg/ml range.


  
immuSpeed chip
immuDrop Chip